Thomas D. Reed, Ph.D.

Biosolution Designer

Entrepreneurial Scientific Leader and Inventor

For over 20 years, Dr. Reed has been a leading creative force and authority on harnessing the power of DNA for a broad range of applications. Dr. Reed was the Founder and Chief Science Officer of Intrexon and the Co-Founder of Precigen Triple-Gene. He recently founded BioSolution Designs, a DNA-based technology company.

During his 20+ year tenure at Intrexon, Dr. Reed pioneered technologies to improve the safety and efficacy of gene and cell therapies. He gained multidisciplinary expertise that enabled advanced technology acquisitions to complement Intrexon’s in-house portfolio and stewarded the growth of commercial operations and business development, including strategic ventures in health, food, environment and consumer sectors.

Dr. Reed architected the genetic platform, as well as, therapeutic candidates for oncology, cardiovascular, and rare disease treatments now advancing in the clinic. Prior to founding Intrexon, Dr. Reed’s scientific training focused on characterizing the structure and function of genes critical for cardiovascular development and pathophysiology.

Education

Ph.D., Molecular and Developmental Biology
University of Cincinnati (1999)

M.S., Biological Sciences
Wright State University (1991)

B.S., Genetics
University of California, Davis (1989)

Experience

Founder & President (2020)

BioSolution Designs, LLC
Boynton Beach, FL
www.biodzn.com

BSD’s leadership has multi-decade experience learning to balance the promise vs reality of employing technologies that meet safety, efficacy, COGS, and consumer acceptance requirements. BSD’s core mission links intellectual property with the scientific and business perspectives required for new product development integrating bioinformatics, synthetic biology, and device engineering disciplines. Employing these synergistic areas of expertise, the BSD team focuses on inventing complex, novel products to meet long-standing market needs.

Founder & Chief Science Officer (1998 – 2020)

Intrexon Corporation*
Germantown, MD

*Renamed Precigen in 2020
www.precigen.com

In 2020, Intrexon changed its name to Precigen, Inc. to reflect its refocused effort on healthcare to address unmet medical needs across a diverse spectrum of therapeutic modalities, including gene and cell therapies, microbial bioproduction, and regenerative medicine.

Intrexon focused on bioengineering solutions for health, food, energy, environment and consumer sectors with numerous first-in-class products trailblazing regulatory paths to market.

Highlights & Accomplishments

Founded DNA-based startup company in 1998 to address commercial opportunities for genomics-based molecular tool technologies and therapeutic products. Secured combined raises of in excess of $100 million USD as private company prior to IPO supporting acquisition and expansion of platform technology applications for development of health, food, energy, environment, and consumer products.

Initiated and Co-led early development of the UltraPorator^® gene delivery system approved by FDA for use in autologous chimeric antigen receptor T cell (UltraCAR-T^®) clinical trials.

Founded BioSolution Designs (BSD) in 2020 to advance new venture opportunities spanning genomics applications across sectors. BSD’s core mission links intellectual property with the scientific and business perspectives required for new product development integrating bioinformatics, synthetic biology, and biomaterial engineering disciplines.

More Highlights & Accomplishments

Founded startup Genomatix LLC during graduate studies at University of Cincinnati (1998)

Performed on-site transgene construction services for Greater Cincinnati Area research labs (1999)

Established independent commercial laboratory in Hamilton County Business Center with ~$300K raised funds (2000)

Executed ~$1M Series A raise for transgene manufacturing expansion and corporate relocation from Cincinnati to the Virginia Tech Corporate Research Center (2004)

Launched cell signaling research tools platform (SubExplorer) to measure phosphorylation dynamics in subcellular compartments (2004)

Formed strategic partnership with RheoGene for RheoSwitch® molecular tools to control gene expression and synergize with the SubExplorer platform (2005)

Raised a $500K Series B-1 Round, changed name from Genomatix to Intrexon Corporation (NewVa Capital Partners) (2005)

Expanded sales and operations with follow-on $1M Series B-2 Round raise (NewVa Capital Partners) (2006)

Raised $5M Series C Round (Third Security, LLC). Transitioned Intrexon from a research tools and transgene services provider to developer of human therapeutics focused on subcellular modulation of phosphorylation dynamics. (2006)

Acquired RheoGene. Integrated core technologies to deliver gene therapies focused on immuno-oncology. (2007)

Raised a $25M Series C-2 Round (Third Security, LLC) to focus on accelerating translation of the RheoSwitch® system into human clinical trials and expand library of therapeutic modulators (2007)

Expanded research and development divisions to ~90 scientists and engineers at VA and PA sites to support UltraVector manufacturing division. Managed integration of multidisciplinary teams including DNA/RNA/protein design teams, as well as chemistry, cell biology, viral production, and software development teams. (2007-09)

Co-led preparation, filing, and clinical management of the Phase 1a Study testing safety of the RheoSwitch® Activator Ligand RG-115932 (2008)

Co-led preparation and filing of the Phase 1b, Open Label Trial to Evaluate the Safety, Tolerance, Transgene Function, and Immunological Effects of an Intratumoral Injection of Adenoviral Transduced Autologous Dendritic Cells Engineered to Express hIL-12 in Subjects With Stage III or IV Melanoma (2008)

Led Molecular Engineering Research Unit (2009-13) and Corporate Technology Analysis Unit (2009-19)

Secured $100M Series E Round. Managed technical strategy and diligence components. (2011)

Advanced drug development strategy for Modular Inducible Cancer Immunotherapy (MICI) enabling Exclusive Channel Collaboration with Ziopharm Oncology (2011)

Co-led acquisition of Agarigen core technologies and formation of AgBio operating division and strategic business sector (2011)

Acquired and integrated Cyntellect and GT Life Sciences to form Cell Engineering Unit (2011); managed operations (2011-13)

Advanced genetically-modified (GM) autologous fibroblast drug development strategy enabling Exclusive Channel Collaboration with Fibrocell Science, Inc., including foundational designs for FCX-007, an autologous GM-Cell therapy for treating Recessive Dystrophic Epidermolysis Bullosa (RDEB) (2012)

Co-led design of chimeric antigen receptor T cell (UltraCAR-T®) therapy product development strategy, including invention, acquisition, and optimization of systems required for scalable decentralization of autologous GM-T Cell production (2012-19)

Led scientific communications critical for completion of Intrexon’s initial public offering ($168.3 million) to drive development of programs addressing bioengineering technology opportunities in health, food, energy, environment, and consumer sectors (2013)

Co-led design of therapeutic candidates for treating Friedrich’s Ataxia, enabling formation and Exclusive Channel Collaboration with Agilis Biotherapeutics (2013)

Led Consumer Sector, including launch of US-based ViaGen Pet Services (2014-15)

Co-founded Xogenex (now Precigen Triple-Gene LLC), a gene therapy company focused on developing advanced therapies for complex cardiovascular diseases. (2014) Managed clinical and business operations. (2018-20)

Acquired GenVec, Inc., a company focused on developing adenoviral-based gene therapies and vaccines. (2017) Co-managed corporate and platform integration. (2018)

Acquired Genomatix, GMBh to further enhance DNA design and bioinformatics capabilities. (2018). Co-managed corporate and platform integration. (2018-19)

Initiated and Co-led early development of the UltraPorator® gene delivery system approved by FDA for use in autologous chimeric antigen receptor T cell (UltraCAR-T®) clinical trials (2016-2019).

Patents

Granted Patents & Active Patent Applications

Therapeutic Inhibitors of PAI-1 Function and Methods of Their Use

Parent application filed in 2010 and granted in US as US8431363; divisional application granted as US8828686.

Therapeutic Gene-Switch Constructs and Bioreactors for the Expression of Biotherapeutic Molecules and Uses Thereof

Granted in the US as US9724430 and US10314926.

Modulating Expression of Polypeptides via New Gene Switch Expression Systems

WO2018132494 filed in 2018 with priority date 2017. Pending in US.

More Granted Patents & Active Patent Applications

Signal for Targeting Molecules to the Sarco(endo)plasmic Reticulum. Filed in US in 2003, granted as US7071295.

Engineered Cells Expressing Multiple Immunomodulators and Uses Thereof. Parent application filed in US in 2011; granted as US9492482 and US10046049.

PKD Ligands and Polynucleotides Encoding PKD. Granted in US as US8153598 and US8993531.

Methods of Making Modular Fusion Protein Expression Products. Granted in US as US8603807.

AKT Ligands and Polynucleotides Encoding AKT Ligands. Parent application filed in US in 2007; granted as US7943732.

PKA Ligands and Polynucleotides Encoding PKA Ligands. Granted in US as US8993263.

PKC Ligands and Polynucleotides Encoding PKC Ligands. Granted in US as US8999666.

Glycogen Synthase Kinase Heteropolyligand Polypeptide. Granted in US as US8729225.

Extracellular-Signal-Regulated-Kinase (ERK) Heteropolyligand Polypeptide. Granted in US as US8283445.

mTOR Ligands and Polynucleotides Encoding mTOR Ligands. Parent application filed in US in 2007; granted as US7705122.

MEK Ligands and Polynucleotides Encoding MEK Ligands. Granted in US as US8575304 and as US9006390.

PP1 Ligands. Granted in US as US8455628.

Therapeutic Inhibitors of PAI-1 Function and Methods of Their Use. Parent application filed in 2010 and granted in US as US8431363.

Endoplasmic Reticulum Localization Signals. Parent application filed in US in 2007; granted as US7897394.

Tubulo-Vesicular Structure Localization Signals. Granted in US as US8993742.

Synthetic 5’UTRs, Expression Vectors and Methods for Increasing Transgene Expression. Parent application filed in US in 2010; granted as US8835621.

Methods and Compositions for Diagnosing Disease. Granted in US as US9222121 and US9605316.

Therapeutic Gene-Switch Constructs and Bioreactors for the Expression of Biotherapeutic Molecules and Uses Thereof. Granted in the US as US9724430 and US10314926.

DNA Cloning Vector Plasmids and Methods for Their Use. Parent application filed in US in 2003; granted as US7785871.

Methods for Dynamic Vector Assembly of DNA Cloning Vector Plasmids. Granted in US as US9115361 and US10036026.

Exosome Delivery of Skin Care Peptides. WO2020018926 filed in 2019 with priority to 2018.

Modulating Expression of Polypeptides via New Gene Switch Expression Systems. WO2018132494 filed in 2018 with priority date 2017. Pending in US.

Presentations

Triple-Gene presents interim clinical data for INXN-4001 Triple Effector Cardiac Gene Therapy

12th Annual Biotech Showcase 2020 organized by EDB Group, San Francisco, CA. (January 15, 2020)

Invited panelist for Council on Competitiveness Briefing to accompany release of “Report on Future of Bioscience and Manufacturing”

Washington DC. (July 25, 2017)

Invited presenter and panelist for National Academies of Sciences, Engineering, and Medicine Committee on Future Biotechnology Products and Opportunities to Enhance Capabilities of the Biotechnology Regulatory System

Washington DC. (April 21, 2016)

Publications

Targeted Inhibition of Ca2+/Calmodulin Dependent Protein Kinase II in Cardiac Longitudinal Sarcoplasmic Reticulum Results in Decreased Phospholamban Phosphorylation at Threonine-17

Structure and Organization of the Mouse ATP2A2 Gene Encoding the Sarco(endo)-plasmic Reticulum Ca2+-ATPase 2 (SERCA2) Isoforms

Impaired Cardiac Performance in Heterozygous Mice with a Null Mutation in Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 2 (SERCA2) Gene

More Publications

Generation of Mice with a Conditional Allele for the Transforming Growth Factor Beta3 Gene. Thomas Doetschman, Teodora Georgieva, Hongqi Li, Thomas D. Reed, Christina Grisham, Jacqueline Friel, Mark A. Estabrook, Connie Gard, L.P. Sanford, and Mohamad Azhar. Genesis. 2012 January; 50(1):59-66.

ERK Regulates Strain-Induced Migration and Proliferation from Different Subcellular Locations. Gayer CP, Craig DH, Flanagan TL, Reed TD, Cress DE, Basson MD. Journal of Cellular Biochemistry. (2010) March; 109(4):711-25.

Outsourcing Molecular Biology Tasks: A Valuable Business Tool for Accelerating Bioprocessing R&D. Thomas D. Reed. BioContract Services (2004) 1:S25-S30.

Targeted Inhibition of Ca2+/Calmodulin Dependent Protein Kinase II in Cardiac Longitudinal Sarcoplasmic Reticulum Results in Decreased Phospholamban Phosphorylation at Threonine-17. Ji Yong, Bailing Li, Thomas Reed, John Lorenz and John Dedman. Journal of Biological Chemistry. (2003) 278:25063-71.

Replacement of the Muscle-Specific Sarcoplasmic Reticulum Ca(2+)-ATPase Isoform SERCA2a by the Nonmuscle SERCA2b Homologue Causes Mild Concentric Hypertrophy and Impairs Contraction-Relaxation of the Heart. Ver Heyen M, Heymans S, Antoons G, Reed T, Periasamy M, Awede B, Lebacq J, Vangheluwe P, Dewechin M, Collen deS, Sipido K, Carmeliet P, Wuytack F. Circulation Research (2001) 89:838-46.

Changes in Ionic Currents and Beta-Adrenergic Receptor Signaling in Hypertrophied Myocytes Overexpressing G alpha(q). Mitari S, Reed TD and Yatani A. American Journal of Physiology. (2000) 279:H139-48.

The Expression of SR Calcium ATPase and the Na+/Ca2+ Exchanger are Antithetically Regulated during Mouse Cardiac Development and in Hypo/Hyperthyroidism. Reed TD, Babu GJ, Ji Y, Zilberman A, Ver Heyen M, Wuytack F, Periasamy M. Journal of Molecular and Cellular Cardiology. (2000) 32:453-64.

Structure and Organization of the Mouse ATP2A2 Gene Encoding the Sarco(endo)-plasmic Reticulum Ca2+-ATPase 2 (SERCA2) Isoforms. Ver Heyen M and Reed TD (co-first authors), Blough RI, Baker DL, Zilberman A, Loukianov E, Van Baelen K, Raeymaekers, L, Periasamy M and Wuytack F. Mammalian Genome (2000) 11:159-63.

Impaired Cardiac Performance in Heterozygous Mice with a Null Mutation in Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 2 (SERCA2) Gene. Periasamy M, Reed TD, Liu LH, Ji Y, Loukianov E, Paul RI, Nieman ML, Miller ML, Riddle T, Duffy JJ, Doetschman, T, Lorenz JN and Shull GE. Journal of Biological Chemistry (1999) 274:2556-62.

Targeted Overexpression of the Sarcoplasmic Reticulum Ca2+-ATPase Increases Cardiac Contractility in Transgenic Mouse Hearts. Baker DL, Hashimoto K, Grupp IL, Ji Y, Reed T, Loukianov E, Grupp G, Bhagwat A, Hoit B, Walsh R, Marban E and Periasamy M. Circulation Research (1998) 83:1205-14.

Sarco(endo)plasmic Reticulum Ca2+ ATPase Isoforms and Their Role in Muscle Physiology and Pathology. Loukianov E, Ji Y, Baker DL, Reed T, Babu J, Loukianov T, Greene A, Shull G and Periasamy M. Annals of the New York Academy of Sciences (1998) 853:251-59.

A Novel E Box/AT-Rich Element is Required for Muscle-Specific Expression of the Sarcoplasmic Reticulum Ca2+-ATPase (SERCA2) Gene. Baker DL, Dave V, Reed T, Misra S and Periasamy M. Nucleic Acids Research (1998) 26:1092-98.

Multiple Sp1 Binding Sites in the Cardiac/Slow Twitch Muscle Sarcoplasmic Reticulum Ca2+-ATPase Gene Promoter are Required for Expression in Sol8 Muscle Cells. Baker D, Dave V, Reed T and Periasamy M. Journal of Biological Chemistry (1996) 271:5921-28.

Characterization of the Mouse Cardiac/Slow-Twitch Muscle-Enhanced Sarco(endo)plasmic Reticulum Calcium ATPase (SERCA2) Gene. Thomas D. Reed. Doctor of Philosophy Dissertation (1998) University of Cincinnati College of Medicine; Cincinnati, Ohio.

A GTP-binding Activity from Bovine Heart Affects Phosphoinositide-Specific Phospholipase C (PIC) Activity. Thomas D. Reed. Master of Science Thesis (1991) Wright State University; Dayton, Ohio.

Posters

Safety of First-in-Human Triple Gene Therapy for Heart Failure Patients

Ewa Jaruga-Killeen, David Bull, Kapildeo Lotun, Timothy Henry, Gregory Egnaczyk, Thomas Reed, Amit Patel. American Heart Association, Scientific Sessions 2019.

Regulated Intratumoral Expression of IL-12 in Combination with Cytotoxic Agents as a Strategy for the Treatment of Metastatic Breast Cancer

John Nemunaitis, Heather McArthur, Clifford Hudis, Thomas Reed, Samuel Broder, Francois Lebel, John Barrett, Jonathan Lewis, Larry Norton. San Antonio Breast Cancer Symposium 2013.

Regulated Immunodulators Expression Using the RheoSwitch Therapeutic System® Platform in Human Mesenchymal Stem Cells

T. Chan, A. Prabhu, A. Elayadi, L. Williams, V. Dailey, K. Elliot, T.S Snipas, J. Carson, J. Lewis, S. Schauer, R. Einstein, J. Rieger, L Humeau and T. Reed. AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 2013.

Public and Community Service

U.S. Council on Competitiveness Technology Leadership & Strategy Initiative Committee

The TLSI is a cross-sectoral, results-driven “action tank” making the business case for strategic, prioritized investments in the research, talent and infrastructure necessary for tech-based innovation…

Wright State University Contributor

Co-sponsored development of the College of Liberal Arts’ (COLA) “Change the World” Curriculum; entrepreneurial programs led by the College of Science and Mathematics (COSM); and collaborative initiative between COSM and COLA’s Department of Theatre, Dance, and Motion Pictures focused on empowering incoming freshmen.

Christ’s Community in College Hill, Trustee, Chairperson

Assisted in operational overhaul and re-budgeting process to enable inter-denominational support for spiritual, physical, emotional, financial, and social needs of residents living in College Hill, Ohio…

More Public Services

U.S. Council on Competitiveness Technology Leadership & Strategy Initiative Committee (2016-19). The TLSI is a cross-sectoral, results-driven “action tank” making the business case for strategic, prioritized investments in the research, talent and infrastructure necessary for tech-based innovation; chaired by Boeing Chief Technology Officer Greg Hyslop, Lockheed Martin CTO Keoki Jackson and Deere & Company VP for Advanced Technology & Engineering Klaus Hoehn and comprising a peer group of CTOs, CSOs and heads of research at leading companies, universities and national laboratories. Click here to learn more about TLSI mission.

Wright State University Contributor

Cincinnati Life Science CEO Roundtable Member (2002-04)

Cincinnati Chamber of Commerce, Regional Entrepreneurial Network, “Voice of the Consumer” High-tech Leadership Committee Member (2002)

Policy Steering Committee Advisor, Chris Monzel for Cincinnati City Council Campaign (2000)

Christ’s Community in College Hill, Trustee (1995-2000), Chairperson (1996-97)

Assisted in operational overhaul and re-budgeting process to enable inter-denominational support for spiritual, physical, emotional, financial, and social needs of residents living in College Hill, Ohio
Coordinated community outreach programs for under-privileged youth and administered volunteer programs to strengthen community, enhance interfaith relationships, and address local challenges including food disparities

CV

Thomas D. Reed, Ph.D.

Biosolution Designer

Entrepreneurial Scientific Leader and Inventor

Education

Experience

Highlights & Accomplishments

Initiated and Co-led early development of the UltraPorator^® gene delivery system approved by FDA for use in autologous chimeric antigen receptor T cell (UltraCAR-T^®) clinical trials.

More Highlights & Accomplishments

Patents

Granted Patents & Active Patent Applications

Therapeutic Inhibitors of PAI-1 Function and Methods of Their Use

Therapeutic Gene-Switch Constructs and Bioreactors for the Expression of Biotherapeutic Molecules and Uses Thereof

Modulating Expression of Polypeptides via New Gene Switch Expression Systems

More Granted Patents & Active Patent Applications

Presentations

Triple-Gene presents interim clinical data for INXN-4001 Triple Effector Cardiac Gene Therapy

Invited panelist for Council on Competitiveness Briefing to accompany release of “Report on Future of Bioscience and Manufacturing”

Invited presenter and panelist for National Academies of Sciences, Engineering, and Medicine Committee on Future Biotechnology Products and Opportunities to Enhance Capabilities of the Biotechnology Regulatory System

More Presentations

Please visit the contact page to inquire further about speaking opportunities.

Publications

Targeted Inhibition of Ca2+/Calmodulin Dependent Protein Kinase II in Cardiac Longitudinal Sarcoplasmic Reticulum Results in Decreased Phospholamban Phosphorylation at Threonine-17

Structure and Organization of the Mouse ATP2A2 Gene Encoding the Sarco(endo)-plasmic Reticulum Ca2+-ATPase 2 (SERCA2) Isoforms

Impaired Cardiac Performance in Heterozygous Mice with a Null Mutation in Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 2 (SERCA2) Gene

More Publications

Posters

Safety of First-in-Human Triple Gene Therapy for Heart Failure Patients

Regulated Intratumoral Expression of IL-12 in Combination with Cytotoxic Agents as a Strategy for the Treatment of Metastatic Breast Cancer

Regulated Immunodulators Expression Using the RheoSwitch Therapeutic System® Platform in Human Mesenchymal Stem Cells

More Posters

Public and Community Service

U.S. Council on Competitiveness Technology Leadership & Strategy Initiative Committee

Wright State University Contributor

Christ’s Community in College Hill, Trustee, Chairperson

More Public Services

Affiliations

Thomas D. Reed, Ph.D.

Thomas D. Reed, Ph.D.

Biosolution Designer

Entrepreneurial Scientific Leader and Inventor

Education

Experience

Highlights & Accomplishments

Initiated and Co-led early development of the UltraPorator® gene delivery system approved by FDA for use in autologous chimeric antigen receptor T cell (UltraCAR-T®) clinical trials.

Patents

Granted Patents & Active Patent Applications

Therapeutic Inhibitors of PAI-1 Function and Methods of Their Use

Therapeutic Gene-Switch Constructs and Bioreactors for the Expression of Biotherapeutic Molecules and Uses Thereof

Modulating Expression of Polypeptides via New Gene Switch Expression Systems

Presentations

Triple-Gene presents interim clinical data for INXN-4001 Triple Effector Cardiac Gene Therapy

Invited panelist for Council on Competitiveness Briefing to accompany release of “Report on Future of Bioscience and Manufacturing”

Invited presenter and panelist for National Academies of Sciences, Engineering, and Medicine Committee on Future Biotechnology Products and Opportunities to Enhance Capabilities of the Biotechnology Regulatory System

Publications

Targeted Inhibition of Ca2+/Calmodulin Dependent Protein Kinase II in Cardiac Longitudinal Sarcoplasmic Reticulum Results in Decreased Phospholamban Phosphorylation at Threonine-17

Structure and Organization of the Mouse ATP2A2 Gene Encoding the Sarco(endo)-plasmic Reticulum Ca2+-ATPase 2 (SERCA2) Isoforms

Impaired Cardiac Performance in Heterozygous Mice with a Null Mutation in Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 2 (SERCA2) Gene

Posters

Safety of First-in-Human Triple Gene Therapy for Heart Failure Patients

Regulated Intratumoral Expression of IL-12 in Combination with Cytotoxic Agents as a Strategy for the Treatment of Metastatic Breast Cancer

Regulated Immunodulators Expression Using the RheoSwitch Therapeutic System® Platform in Human Mesenchymal Stem Cells

Public and Community Service

U.S. Council on Competitiveness Technology Leadership & Strategy Initiative Committee

Wright State University Contributor

Christ’s Community in College Hill, Trustee, Chairperson

Affiliations

Initiated and Co-led early development of the UltraPorator^® gene delivery system approved by FDA for use in autologous chimeric antigen receptor T cell (UltraCAR-T^®) clinical trials.